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Immunology

Immunology is Everything!

Our specialisation is immunology. We have a track record in experimental immunology. We provide experimental services on immunological systems. The work maybe part of developing an assay to test an immune based product or to test the immune responses to a biomolecule.

 

IMMUNE MODELLING

Immunology is an essential part of most biological systems and in many instances the immune response to inflammation and regulation is the central issue in a disease system. The way we understand the immune system and the central dogma of the immune response have changed significantly in recent decades, so that it is becoming increasingly important to know the immune dynamics of a disease or a candidate biomolecule in a disease system. In the ‘Systems Biology’ approach to disease systems and drug discovery immunology has become an essential element.

For example, in vascular calcification events that lead on to atherosclerosis the prelude is inflammation, hence it is important to understand the roles of pro-inflammatory and regulatory mediators in driving the transformation of smooth muscle cells into osteoblast-like cells within a vascular calcification model. Another example, heat shock proteins, the chaperones that are widely abundant proteins, are also known to be actively involved in the presentation of danger to APCs initialising an immune response, hence the role of HSPs in the immunology of diseases such as autoimmunity or cancer should be an important query.

Immune systems_diagram (4)

We emphasise on the immune modelling of a disease or a candidate therapeutic to understand:

–   what is the immune profile of the disease and why is it important?

–   What is the immune response to the candidate biomolecule, and is it important?

As experienced immunologists we will help you design and test a model to analyse the immunology of your subject or product.

 

TRANSGENIC DESIGNS

It is often necessary to design and create a transgenic model that is customised to serve your research. We will help you in developing a new transgenic model. Professor Werner Muller based in Manchester and with additional resources in Germany is a key scientist in transgenic technology, in particular cell specific gene targeting. Cell specific gene targeting enables us to modify the expression of a protein on a specific cell for example the deletion of the IL-10R on dendritic cells only, which is useful in characterising the function or signalling of the protein in relationship to the cell. Prof. Muller has developed many transgenic mouse models that are used by many scientists around the world including the UK, the US, Germany, Japan, Israel and Australia.

 

GENERAL IMMUNE SERVICES

We offer general immune assay development services. These services include:

ANTIBODY REPERTOIRE

(in development)

Our body goes through various immunogenic responses through our lifetime, most of which are tolerated. This creates an antibody repertoire within our immune system which potentially interacts with any particle that enters our body system. In the course of a drug development it would be rational and ideal to study the candidate against a known repertoire of antibodies. The antibody repertoire will be, as expected, different in each person, nevertheless we can assume that there will be a consensus form that could be applicable to general populations. Antibody immune responses against biological drugs and ‘Immune Mediated Adverse Drug Reactions’ are now a known phenomenon and there is increasing evidence to support that drug discovery should include it as part of their study to eliminate possibilities of such adverse reactions. The antibody repertoire may contribute to resistance to and even adverse reactions to drugs.

We are in the process of developing a screening system for drugs against antibody repertoires. In addition to PK and ADME studies, this will effectively help you develop a drug that is safe.